Stroke Archive

Research we're watching

Infections — especially those in the urinary tract, known as UTIs — may raise the risk of a stroke, a new study finds.

Researchers examined the electronic medical records of more than 191,000 stroke patients to see if they'd been hospitalized or gone to an emergency room for an infection shortly before the stroke. They tracked infections of the abdomen, blood, respiratory tract, skin, or urinary tract.

A substance called trimethylamine N-oxide, which is produced when your body digests red meat, may raise the risk of cardiovascular problems.

Experts used to think that red meat raised your risk of heart disease simply because it was high in saturated fat. But today that picture has gotten more complicated thanks to the discovery of a metabolite — a substance produced during digestion and metabolism — called trimethylamine N-oxide, or TMAO.

According to a news article published June 11 in JAMA, three recent analyses have linked high blood levels of TMAO with a higher risk for both cardiovascular disease and early death from any cause. In one of those studies, researchers found that people with higher levels of TMAO in their blood may have more than twice the risk of heart attack, stroke, or other serious cardiovascular problems, compared with people who have lower levels. Other studies have found links between high TMAO levels and heart failure and chronic kidney disease.

Ask the doctor

Q. My cardiologist mentioned that he was going to do a "bubble study" during my echocardiogram. What is that?

A. During an echocardiogram, a technician uses a probe that emits high-frequency sound waves (ultrasound) that "echo" off the structures of your heart. The waves, which are translated into video images visible on a monitor, can reveal in-formation about your heart's structure and function. A bubble study gives added information, as it can identify potential blood flow issues inside your heart.

In the journals

Even if you believe you're in excellent health, you could still be at risk for a heart attack or stroke, suggests a study of more than 6,800 people, average age 62, published Feb. 15, 2019, in JAMA Network Open. At the study's beginning, participants rated their health as excellent, very good, good, or poor/fair. (More than half the men reported being in very good or excellent health.)

Next, everyone had a coronary artery calcium (CAC) scan, which detects plaque buildup in the arteries of the heart. The scores range from zero to 100 and higher, with zero meaning no plaque buildup is present and cardio-vascular disease risk is at its lowest.

Research we're watching

Contrary to observations that moderate drinking (one or two drinks per day) protects against stroke, a new study finds that stroke risk may rise with increasing alcohol intake.

The findings, which were published online April 4 by The Lancet, come from a study involving 160,000 Chinese adults who reported their drinking habits. They also were tested for gene variants common in Asian populations that cause an unpleasant flushing reaction after drinking. Only 2% of women reported drinking alcohol, compared with 33% of men, so the findings focus mainly on men.

Even short-lived, subtle stroke symptoms should be evaluated.

Imagine trying to write a note, but it feels like you're moving the pen through wet concrete. Or you suddenly can't see normally — it's as if a black curtain has dropped over one of your eyes.

If these odd symptoms last for only a few minutes, you might be tempted to brush them off and blame muscle cramps or fatigue. Don't make that mistake, says Dr. Christopher Anderson, director of Acute Stroke Services at Harvard-affiliated Massachusetts General Hospital. Both of the above scenarios are examples of a possible transient ischemic attack (TIA), commonly referred to as a ministroke. Caused by a temporary lack of blood in part of the brain, a TIA is a warning sign that you are at risk for a stroke.

Learn how to recognize and prevent this dangerous condition, known as venous thromboembolism, or VTE.

When a blood clot blocks an artery supplying the heart or the brain, the result is a heart attack or stroke. Most Americans are familiar with these two serious health threats. But they're probably less familiar with the dangers of venous thromboembolism, or VTE — a clot that forms in a vein.

A clot in the leg or arm, known as deep-vein thrombosis, can cause pain, swelling, and redness in the affected limb. But the real threat occurs if the clot breaks off and travels to the lungs, causing a pulmonary embolism.

In the journals

People who have had a heart attack or a stroke are routinely prescribed a statin to reduce the risk of a repeat event. But by also following a Mediterranean-style diet, they can improve their chance of living longer, suggests a study in the Feb. 1, 2019, issue of the International Journal of Cardiology.

The study looked at 1,180 people, average age 68, who had at least one previous heart attack or stroke, and recorded their statin use and diet intake at the study's beginning. The researchers identified the people who faithfully followed a Mediterranean-style diet. A Mediterranean-style diet involves consuming medium to high amounts of whole fruits and vegetables, whole grains, legumes and nuts, olive oil, and poultry and fish, with limited amounts of red meat, alcohol, and dairy.

At 70 years and counting, the Framingham Heart Study continues to help doctors better understand stroke, dementia, and heart disease.

 Image: © BHPix/Getty Images

In 1948, more than 5,200 people living in a town just west of Boston volunteered for what has evolved into the longest running and best-known study of the causes of heart disease. But the multigenerational Framingham Heart Study has also revealed important clues about brain disorders — most notably stroke but also cognitive decline and dementia (see "Framingham's brain health findings").

In the early 1960s, Framingham researchers coined the term "risk factor," which refers to a characteristic or exposure that raises a person's odds of developing a disease. Over the following decades, they uncovered many such factors for heart disease, including cigarette smoking, obesity, lack of physical activity, and high blood pressure. These habits and conditions also turned out to predispose people to stroke and dementia, thereby establishing that what harms the heart is also bad for the brain.

People with fluctuating numbers — like blood pressure, cholesterol, and weight — may be at higher risk of heart attack, stroke, and even death.

 Image: © RapidEye/Getty Images

Most people battle "yo-yoing" at some point, when their weight, blood pressure, or some other health number keeps going up and down.

On the surface, this may not seem like a problem if you routinely hit the healthy numbers. Yet new research suggests that fluctuations like this may pose a greater health risk than staying at a single level, even if it's not a perfect one.