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Intermittent hormone therapy: A patient’s story

March 11, 2009
  • By Harvard Prostate Knowledge


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Ronald May
October 10, 2015

The article is very interesting since I’m 82 had a PSA of 10 and a Gleason score of 3+4 before starting ADT and radiation in Jan. 2015.Since Jan. I’ve had three treatments wih Lupron with PSA readings of <.01&.02.I know my Doctor would like to continue treatment for up to two yrs.,I'm seriously considering stopping and following future PSA readings in regards to re-starting.My motive is to improve quality of life with intermittent therapy.Thanks for the article.

Joe Bryant
September 23, 2015

My treatment and results have never followed the pattern predicted by my Doctor. In march 2011 a DRE exam and a rise in psa to 4.2 from 2.3 the previous year suggested a biopsy was required. A biopsy came back with a gleason score of 7(4+3) t2a, 5 of 12 cores with cancer and no symptoms. MRI’s & bone scans were negative so IGMRT radiation(8100 GY, seminal vessels total dose of 45GY) began and was completed with no collateral damage.I was told to expect my psa to gradually go down except for a possible short term bounce. Instead my psa rose to 7.9 in 3 months so suspecting metastasis they ordered mor MRI & bone scans which came back negative. My psa continued to rise to 15.7 by june 2012 so I started ADT hormone therapy and continued for 2 years until my psa went down .1. MRI’s and bone scans were ordered again in june 2012 and came back negative. I decided to stop the hormone therapy then and check my psa every 6 months. The first reading was .7 and after one year jumped to 6.3-2 months later to 10.06 in August 2015 so I resumed ADT hormone therapy. So after all this treatment over the past 4 years I have no symptoms of cancer, 3 recent DRE’s indicated a small flat, smooth prostate with no sign of a tumor, but a rapidly rising psa without hormone therapy. I will continue to use intermittent therapy because I’m very concerned about the bone and other possible deterioration caused by ADT because though I am 82 years old my health is excellent except for this problem. The really frustrating aspect is that no one can tell me for sure if I have active cancer. Everything is based upon a rising psa.

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